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2021-04-06 2019-04-29 Homo sapiens (human) microRNA hsa-mir-21 precursor sequence is a product of hsa-mir-21 precursor, mir-21 precursor, 21, MIR21, mir-21 precurso, mir-21 genes. Found in the human reference genome. Genome locations. Sorry, there was a problem loading genome locations from server.
MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15-27 nucleotides in length that regulate gene expression at the post-translational level. miR-21 is one of the earliest identified cancer-promoting ‘oncomiRs’, targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion. Abbreviations: CIs = confidence intervals, LC = lung cancer, mRNA 21 = microRNA 21. How to cite this article: Qiao F, Luo P, Liu Ch, Fu K, Zhao Yb. Association between microRNA 21 expression in serum and lung cancer: A protocol of systematic review and meta-analysis. Medicine. 2020;99:22(e20314). FQ and PL have contributed equally to this study.
MiR-21 is up-regulated in both periodontitis patients and the mice that induced with periodontitis. Wu H, Ng R, Chen X, Steer CJ and Song G: MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut gutjnl-2014-308430.
Gaspar Dip Júnior, N: Análise de Expressão de micro RNA em C
Visualizing a protonated RNA state that modulates microRNA-21 maturation. Micro RNA expression may be an independent risk factor for patient with 16 Dec 2011 RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes.
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Here, we report the use of a small molecule microarray (SMM) screening approach to identify low molecular weight compounds that directly 2019-10-04 · Background The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upstream of P38 MAPK and was upregulated in mouse hearts upon CVB3 infection. However, the effect and underlying mechanism of miRNA-21 on CVB3 infection remain unclear.
miR-21 promotes cumulus expansion and oocyte maturation via down-regulating TIMP3; miR-21 plays important roles in reproduction regulation during porcine estrous. 2019-04-29 · Asangani IA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2008;27(15):2128–2136.
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MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC. In this study, 50 GC patients and 50 healthy controls were recruited. miR-21 levels in serum and peripheral blood mononuclear cells (PBMCs) were quantified using quantitative real-time PCR. T1 - MicroRNA-21-enriched exosomes as epigenetic regulators in melanomagenesis and melanoma progression. T2 - The impact of western lifestyle factors.
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Diseases associated with MIR21 include Oral Squamous Cell Carcinoma and Glioma. Among its related pathways are Nanoparticle triggered autophagic cell death and Proteoglycans in cancer Introduction. microRNA-21 negatively regulates several targets, and thus impacts tumorigenesis. However, the exact mechanism of action in human gastric carcinoma is poorly understood, and there is currently no direct evidence that demonstrates a correlation between microRNA-21 function and phenotype.
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In this work, we studied the roles of microRNA-21 (miR-21) in periodontitis. MiR-21 is up-regulated in both periodontitis patients and the mice that induced with periodontitis. Wu H, Ng R, Chen X, Steer CJ and Song G: MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway.
Multipla mikroRNA modulerar p21Cip1 / Wafl-uttryck genom
2005 ; 65 (14) : 6029-6033. PMID 16024602 : Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Cheng AM, Byrom MW, Shelton J, Ford LP MikroRNA, Mikro-RNA, miRNA on lyhyt, parin kymmenen nukleotidin pituinen, yksijuosteinen RNA-molekyyli, joka estää tietyn lähetti-RNA:n toiminnan kiinnittymällä siihen eli se hiljentää geenin. Monet mikro-RNA:ista ovat proteiinia koodaamattomilta DNA-alueilta. 2008-11-30 · Here we show that microRNA-21 (miR-21, also known as Mirn21) regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function. MicroRNA-21 (miR-21) is a key regulator in the macrophage inflammatory response.
PY - 2020. Y1 - 2020 MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular system.